Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal
Both HRP2 and LDH contributed to the sensitivity of the best-performing Pf-RDT. In populations such as this with low rates of hrp2/hrp3 deletions, the PfLDH line alone cannot compensate for the performance of the HRP2 line, even with the improved PfLDH LOD of the BIOCREDIT tests. RDT analytical LODs can be used to predict performance in populations with known antigen concentrations.
Authors
- Gonzalo J. Domingo (ORCID: https://orcid.org/0000-0002-1004-4395)
- Fatoumata Diène Sarr
- Babacar Souleymane Sambe (ORCID: https://orcid.org/0000-0001-5983-2248)
- Allison Golden (ORCID: https://orcid.org/0000-0001-6891-5176)
- William Sheahan (ORCID: https://orcid.org/0000-0002-4192-4491)
- Ihn Kyung Jang (ORCID: https://orcid.org/0000-0001-8899-7930)
- Sampa Pal (ORCID: https://orcid.org/0000-0001-9898-8886)
- Hannah Slater (ORCID: https://orcid.org/0000-0003-4291-7899)
- Serigne Ousmane Mbacké Diaw
- Arona Sabène Diatta
- Moustapha Cissé
- Makhtar Niang (ORCID: https://orcid.org/0000-0003-0810-4595)
- Inès Vigan-Womas (ORCID: https://orcid.org/0000-0001-7848-9297)
- Stephanie Zobrist (ORCID: https://orcid.org/0000-0001-9436-9885)
- Ibrahima Sarr
- Joseph Faye
- Yakou Dieye
- Aissatou Diagne (ORCID: https://orcid.org/0009-0007-0130-3184)
- Nerie Roa
- Divya Soni
Institutions
- Program for Appropriate Technology in Health (US)
- Program for Appropriate Technology in Health (IN)
- Institut Pasteur de Dakar (SN)
- Seattle University (US)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s13071-025-06914-9
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Bill and Melinda Gates Foundation
- Institute of Translational Health Sciences
- National Institutes of Health
- National Center for Advancing Translational Sciences