Bilateral adduction palsy with a paramedian midbrain lesion is most likely wall-eyed bilateral oculomotor subnuclear ophthalmoplegia: a case report of a brainstem infarction

A 73-year-old female was hospitalized in our Department of Neurology for diplopia due to multiple infarctions in the midbrain and pons. A neurological examination revealed bilateral adduction palsy during horizontal gaze with nystagmus of the contralateral abducting eye. Exotropia and impaired convergence were also noticed. The distinctive symptoms indicated wall-eyed bilateral internuclear ophthalmoplegia (WEBINO). We speculate that the cause of WEBINO in our case was bilateral medial rectus palsy <i>via</i> bilateral damage to the medial rectus subnuclei (MRSN) due to the paramedian midbrain infarction. We propose that bilateral adduction palsy with impaired convergence due to bilateral MRSN impairment, such as in our case, should be given a more appropriate name because we speculate that it is not 'internuclear ophthalmoplegia'. 'WEBOSO' (wall-eyed bilateral oculomotor subnuclear ophthalmoplegia) may be a more appropriate name.

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Publication Details

Journal
International Journal of Neuroscience
Published
2025-07-12
DOI
https://doi.org/10.1080/00207454.2025.2534403
Primary Topic
Ophthalmology and Eye Disorders
Type
article
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article

Bilateral adduction palsy with a paramedian midbrain lesion is most likely wall-eyed bilateral oculomotor subnuclear ophthalmoplegia: a case report of a brainstem infarction

Akihiko Shimomura, Ayaka Chikada, Sho Fujiwara, Tsutomu Yasuda et al.
International Journal of Neuroscience
Ophthalmology and Eye Disorders
article

Bilateral adduction palsy with a paramedian midbrain lesion is most likely wall-eyed bilateral oculomotor subnuclear ophthalmoplegia: a case report of a brainstem infarction

Akihiko Shimomura, Ayaka Chikada, Sho Fujiwara, Tsutomu Yasuda, Noritoshi Arai
article en

Abstract

A 73-year-old female was hospitalized in our Department of Neurology for diplopia due to multiple infarctions in the midbrain and pons. A neurological examination revealed bilateral adduction palsy during horizontal gaze with nystagmus of the contralateral abducting eye. Exotropia and impaired convergence were also noticed. The distinctive symptoms indicated wall-eyed bilateral internuclear ophthalmoplegia (WEBINO). We speculate that the cause of WEBINO in our case was bilateral medial rectus palsy <i>via</i> bilateral damage to the medial rectus subnuclei (MRSN) due to the paramedian midbrain infarction. We propose that bilateral adduction palsy with impaired convergence due to bilateral MRSN impairment, such as in our case, should be given a more appropriate name because we speculate that it is not 'internuclear ophthalmoplegia'. 'WEBOSO' (wall-eyed bilateral oculomotor subnuclear ophthalmoplegia) may be a more appropriate name.

International Journal of NeuroscienceVol. 136(3)
National Center for Global Health and Medicine (JP), Center for Global Health (US)
Gender equality
Openalex Percentile: Top 75%
Ophthalmology and Eye Disorders
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