Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings
Evidence suggests a risk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns.
Authors
- Nemésio Florence Filho (ORCID: https://orcid.org/0000-0003-3781-5716)
- Sandra Helena Alves Bonon (ORCID: https://orcid.org/0000-0002-0630-5062)
- Antonio Carlos de Quadros (ORCID: https://orcid.org/0000-0003-4936-4342)
- Antônio Fernandes Moron (ORCID: https://orcid.org/0000-0002-7963-1758)
- Ana Alarcón (ORCID: https://orcid.org/0000-0001-7223-2028)
- Edison Luíz Durigon (ORCID: https://orcid.org/0000-0003-4898-6553)
- M Leite (ORCID: https://orcid.org/0000-0002-0824-9308)
- Alfredo García‐Alix (ORCID: https://orcid.org/0000-0002-7972-8453)
- Geovane Ribeiro dos Santos (ORCID: https://orcid.org/0000-0002-5411-9870)
- Sérgio Vranjac
- Vera Paiva
- Rita de Cássia de Aguirre Bernardes Dezena (ORCID: https://orcid.org/0000-0001-9096-6308)
- Daniel Thomé Catalan (ORCID: https://orcid.org/0000-0003-1898-8339)
- Eduardo Bagne
- Danielle Bruna Leal Oliveira (ORCID: https://orcid.org/0000-0002-0534-0886)
- Maria Manoela Duarte Rodrigues (ORCID: https://orcid.org/0000-0002-9918-166X)
- Rosa Estela Gazeta (ORCID: https://orcid.org/0000-0003-2527-9880)
- Márcia Borges Machado (ORCID: https://orcid.org/0000-0003-3450-8921)
- Antoni Soriano‐Arandes (ORCID: https://orcid.org/0000-0001-9613-7228)
- Tathiana Ghisi de Souza (ORCID: https://orcid.org/0000-0001-9957-1222)
- Juliana Paula Gomes de Almeida (ORCID: https://orcid.org/0000-0002-5692-5577)
- Fernando Novo Arita
- Andrea Cristina Botelho da Silva (ORCID: https://orcid.org/0009-0006-8092-6656)
- Fernanda Guerra Velasco
- Saulo Duarte Passos (ORCID: https://orcid.org/0000-0002-0908-2677)
- Clóvis Antônio Lopes Pinto (ORCID: https://orcid.org/0000-0003-1711-0081)
- Francisco Del Moral Hernandez (ORCID: https://orcid.org/0009-0007-5655-1548)
- Dirce Takako Fujiwara
- Stéphanno Gomes Pereira Sarmento (ORCID: https://orcid.org/0000-0002-4456-1905)
- Alify Bertoldo da Silva (ORCID: https://orcid.org/0000-0003-2442-6826)
- Ana Paula Antunes Pascalicchio Bertozzi (ORCID: https://orcid.org/0000-0002-2244-1523)
- Raquel Prestes (ORCID: https://orcid.org/0000-0002-3563-2505)
- Viviane Cristina Martori Pandini (ORCID: https://orcid.org/0000-0001-6232-8376)
- Thamirys Cosmo Grillo Fajardo (ORCID: https://orcid.org/0000-0003-1096-1078)
- Mayana Zatz (ORCID: https://orcid.org/0000-0003-3970-8025)
- Alexandra Siqueira Mello
- L Baran (ORCID: https://orcid.org/0000-0002-6683-0686)
- L Castro (ORCID: https://orcid.org/0000-0002-0475-8287)
- Maria de Fátima Valente Rizzo
- Dora Fix Ventura (ORCID: https://orcid.org/0000-0002-7616-4031)
- Sérgio Rosemberg (ORCID: https://orcid.org/0000-0001-8843-8557)
- Diego da Silva Lima (ORCID: https://orcid.org/0000-0003-1526-7712)
- Danilla Soares Tambalo
- Karen Richter Camandulli
- Maria Amélia Farrão
- Patrícia Carvalho Loiola
- Steven Sol Witkinchi
Institutions
- AC Camargo Hospital (BR)
- Hospital Infantil Joana de Gusmão (BR)
- Faculdade de Medicina de Jundiaí (BR)
- Hospital São Paulo (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Revista do Instituto de Medicina Tropical de São Paulo
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/s1678-9946202567043
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00