Effects of a low-dose combination therapy of zoledronate and dexamethasone on post-tooth extraction socket healing: a pre-clinical study in mice

Our findings showed that co-administering low doses of ZL and DX in young male mice augmented the recuperative processes of their post-extraction sockets when juxtaposed with either agent in isolation. Nevertheless, further comprehensive inquiries are needed to delineate the precise underlying mechanisms in a more controlled experimental context.

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Publication Details

Journal
Journal of Applied Oral Science
Published
2025-01-01
DOI
https://doi.org/10.1590/1678-7757-2024-0574
Primary Topic
Bone health and treatments
Type
article
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article

Effects of a low-dose combination therapy of zoledronate and dexamethasone on post-tooth extraction socket healing: a pre-clinical study in mice

Raquel Barroso Parra da Silva, Ana Julia Moreno Barreto, Rafael Carneiro Ortiz, Mariza Akemi Matsumoto et al.
Journal of Applied Oral Science
Bone health and treatments
article

Effects of a low-dose combination therapy of zoledronate and dexamethasone on post-tooth extraction socket healing: a pre-clinical study in mice

Raquel Barroso Parra da Silva, Ana Julia Moreno Barreto, Rafael Carneiro Ortiz, Mariza Akemi Matsumoto, Edílson Ervolino, Antônio Hernandes Chaves-Neto, Letícia Citelli Conti, Cláudia Cristina Biguetti, Alaíde Gonçalves
article en

Abstract

Our findings showed that co-administering low doses of ZL and DX in young male mice augmented the recuperative processes of their post-extraction sockets when juxtaposed with either agent in isolation. Nevertheless, further comprehensive inquiries are needed to delineate the precise underlying mechanisms in a more controlled experimental context.

Journal of Applied Oral ScienceVol. 33
Universidade de São Paulo (BR), The University of Texas Rio Grande Valley (US), Universidade Brasil (BR), Universidade Sagrado Coração (BR), Universidade Estadual do Norte do Paraná (BR), Universidade Estadual Paulista (Unesp) (BR)
Openalex Percentile: Top 75%
Bone health and treatments
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