Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension
Our findings revealed that both ventricles showed structural remodeling but only the RV underwent electromechanical alteration, while the LV displayed metabolic and inflammatory alteration. This was further validated by the preserved EF in the advanced stage of PAH. Our work highlights that a more comprehensive understanding of PAH pathophysiology can lead to targeted therapeutic strategies, challenging the conventional RV-centric perspective.
Authors
- Gianluigi Condorelli (ORCID: https://orcid.org/0000-0003-0481-6843)
- Mirko Hu (ORCID: https://orcid.org/0000-0001-8395-8051)
- Alessia Caputo
- Giacomo Rozzi (ORCID: https://orcid.org/0000-0002-5085-4819)
- Aderville Cabassi (ORCID: https://orcid.org/0000-0001-8262-5669)
- Stefano Rossi (ORCID: https://orcid.org/0000-0002-9022-4096)
- Margherita Burattini (ORCID: https://orcid.org/0000-0002-6899-5791)
- Francesco Paolo Lo Muzio (ORCID: https://orcid.org/0000-0002-4730-2458)
- Rosario Statello (ORCID: https://orcid.org/0000-0002-0644-2454)
- Lorenzo Fassina (ORCID: https://orcid.org/0000-0002-5587-4632)
- Silvia Berrettoni
- Barbara Montanini (ORCID: https://orcid.org/0000-0002-5419-7975)
- Michele Miragoli (ORCID: https://orcid.org/0000-0002-4058-4368)
- Giovanna Pelà (ORCID: https://orcid.org/0000-0001-7676-7281)
- Giovanni Battista Luciani (ORCID: https://orcid.org/0000-0003-0931-018X)
- Roberta Maestri
Institutions
- University of Verona (IT)
- University of Parma (IT)
- University of Pavia (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Deutsches Herzzentrum der Charité (DE)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s12967-025-06792-w
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Dipartimenti di Eccellenza
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Parma