TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy
TGF-β3 potentially acts as a protective factor in PCa by promoting vascular normalization and remodeling of the tumor environment, which facilitates infiltration of CD8<sup>+</sup> T cells or drugs, significantly enhancing their antitumor effects.
Authors
- Qiliang Teng (ORCID: https://orcid.org/0000-0002-8206-6278)
- Xuanqi Wang (ORCID: https://orcid.org/0009-0006-2764-7084)
- Niu Wang (ORCID: https://orcid.org/0009-0003-4050-1870)
- Jiawei Yang (ORCID: https://orcid.org/0000-0001-6632-2238)
- Jun Pang (ORCID: https://orcid.org/0000-0003-0024-9415)
- Bin Xu (ORCID: https://orcid.org/0000-0002-0490-9540)
- Hanqi Lei
- Ya Ruth Huo (ORCID: https://orcid.org/0000-0001-6282-7677)
- Tongyu Tong (ORCID: https://orcid.org/0000-0002-5421-0666)
- Yupeng Guan (ORCID: https://orcid.org/0000-0003-3438-8982)
- Zhenyu Wang
- Bo Zhao (ORCID: https://orcid.org/0000-0003-0097-0077)
- Fu‐Ying Tian
- Mengjun Huang (ORCID: https://orcid.org/0000-0002-3341-8011)
- Wenping Chen (ORCID: https://orcid.org/0000-0003-2673-1111)
- Fei Cao (ORCID: https://orcid.org/0000-0001-9171-2465)
- Ran Bi (ORCID: https://orcid.org/0009-0004-9201-5310)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1007/s00262-025-04103-2
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- China Postdoctoral Science Foundation
- Sanming Project of Medicine in Shenzhen
- Basic and Applied Basic Research Foundation of Guangdong Province