Single-cell RNA sequencing and multi-omics analysis of prognosis-related staging in papillary thyroid cancer
This study introduces OSPTCC, a prognostically significant molecular classification for PTC based on tumor cell differentiation states. The identified subtypes, characterized by distinct biological mechanisms, provide deeper insights into PTC's molecular pathology and offer a framework for improved risk stratification and potential precision therapies.
Authors
- Simo Chen
- Ruting Xie
- Hanlin Sun (ORCID: https://orcid.org/0000-0002-1427-0365)
- Xuechen Sun
- Zhengyan Chang (ORCID: https://orcid.org/0000-0002-9785-9756)
- Runzhi Huang (ORCID: https://orcid.org/0000-0003-2302-7305)
- Le Chang (ORCID: https://orcid.org/0000-0002-6154-7304)
- Ji Guo
- Lijun Zheng (ORCID: https://orcid.org/0000-0002-2890-7494)
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Changhai Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1007/s00262-025-04101-4
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program