Role of AT1angiotensin receptor antagonist in pulmonary complications induced by renal ischemia-reperfusion injury in male and female rats
Our findings suggest that AT1R blockade with losartan confers a gender-dependent protective effect. Specifically, losartan may mitigate IR-induced renal and pulmonary damage in females, potentially through modulation of the nitric oxide pathway and attenuation of oxidative stress.
Authors
- Aghdas Dehghani (ORCID: https://orcid.org/0000-0002-9833-7335)
- Tuba Abbasi
- Seyed Alireza Sobhani (ORCID: https://orcid.org/0000-0002-9962-8986)
- Saeedeh Khajeh Ahmadi (ORCID: https://orcid.org/0000-0002-5691-4237)
- Samin Nahavandi
Institutions
- Hormozgan University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s12882-025-04323-9
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hormozgan University of Medical Sciences