Real-world effectiveness and safety of first-line chemoimmunotherapy combinations in metastatic non-small cell lung cancer with programmed death ligand-1 < 50%: results from an Italian observational study
In this real-world study, chemoimmunotherapy combinations demonstrated manageable toxicity profiles, with effectiveness comparable to that reported in pivotal phase 3 randomized trials. Pembrolizumab and nivolumab/ipilimumab showed similar real-world effectiveness but significantly different toxicity profiles.
Authors
- Emanuela Vattemi
- Ettore D’Argento (ORCID: https://orcid.org/0000-0001-8802-9876)
- Floriana Morgillo (ORCID: https://orcid.org/0000-0002-9167-323X)
- Antonino Bianco (ORCID: https://orcid.org/0000-0001-8334-6581)
- Rita Chiari (ORCID: https://orcid.org/0000-0002-7649-273X)
- Stefania Gori (ORCID: https://orcid.org/0000-0001-6320-405X)
- Emilio Bria (ORCID: https://orcid.org/0000-0002-2333-704X)
- Elio Gregory Pizzutilo (ORCID: https://orcid.org/0000-0002-1440-1820)
- Stefano Boemler Busato
- Antonella Cristofano
- Carminia M. Della Corte (ORCID: https://orcid.org/0000-0002-3396-8099)
- Marco Russano (ORCID: https://orcid.org/0000-0002-6963-3864)
- Anthony DelConte
- Marina Gilli
- Daniele Piscazzi (ORCID: https://orcid.org/0000-0003-0101-1863)
- Clementina Savastano
- Daniele Galanti (ORCID: https://orcid.org/0000-0002-7917-1886)
- Vincenzo Sforza (ORCID: https://orcid.org/0000-0001-7828-3854)
- Alessandro Inno (ORCID: https://orcid.org/0000-0001-6331-6908)
- Denis Occhipinti (ORCID: https://orcid.org/0000-0003-0667-5458)
- Francesco Verderame (ORCID: https://orcid.org/0000-0001-5746-2845)
- Antonello Veccia (ORCID: https://orcid.org/0000-0002-8804-7094)
- Stefania Kinspergher
- Fabiana Vitiello (ORCID: https://orcid.org/0009-0007-2984-4257)
- Carlo Genova (ORCID: https://orcid.org/0000-0003-3690-8582)
- Giovanni Palazzolo
- Cristina Mazzi (ORCID: https://orcid.org/0000-0002-4561-3447)
- Alberto Pavan (ORCID: https://orcid.org/0000-0003-4695-0100)
- Francesca Colamartini (ORCID: https://orcid.org/0009-0002-5183-8770)
- Fabiana Marchetti
- Alessandra Dessì
- Fiorella Lombardo
Institutions
- University of Padua (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Ospedaliera di Perugia (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Ospedale Sacro Cuore Don Calabria (IT)
- Casa di Cura Villa Garda (IT)
- Azienda Sanitaria Locale di Asti (IT)
- Ospedale Santa Maria (IT)
- National Cancer Institute (UA)
- Ospedale di Mirano (IT)
- Ospedale Monaldi (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Campus Bio Medico University Hospital (IT)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Ospedale Policlinico San Martino (IT)
- Ospedale Buccheri la Ferla Fatebenefratelli (IT)
- Azienda Ospedaliera G. Brotzu (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1007/s00262-025-04125-w
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14