RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis
This study is the first to demonstrate that RAD51 promotes radiotherapy resistance in NPC cells by suppressing Caspase-8-dependent pyroptosis. These findings suggest that targeting RAD51 may represent a novel strategy to overcome radioresistance and improve therapeutic outcomes in NPC.
Authors
- Meng Xu (ORCID: https://orcid.org/0000-0001-9366-5746)
- Tan-Huan Chen
- Fuchuan Xie
- Xinyu Zhang
- Jian Song (ORCID: https://orcid.org/0009-0007-3032-9981)
- Yunming Tian
Institutions
- Huizhou Central People's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1007/s12672-025-03100-2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00