Development and Evaluation of Controlled Release Matrix Microspheres of Doxazosin using HPMC and Carbopol

Objective: This study aims to develop and evaluate controlled release matrix microspheres of Doxazosin, a poorly water-soluble antihypertensive drug, to overcome limitations associated with conventional oral dosage forms, including fluctuating plasma levels and frequent dosing. Methods: Microspheres were formulated using Hydroxypropyl Methylcellulose (HPMC K15) and Carbopol via the emulsion solvent evaporation technique. A series of ten formulations were developed and characterized for drug entrapment efficiency, mean particle size, micromeritic properties, and in-vitro drug release. FTIR and DSC studies were conducted to assess drug–excipient compatibility. Drug release kinetics were analyzed using various mathematical models.