Identity by descent and local ancestry mapping of HCV spontaneous clearance in populations of diverse ancestries

IBD is based on sharing of haplotypes and is most powerful in populations with a shared founder or recent common ancestor. For the complex trait of HCV clearance, we used two outbred, global populations that limited our power to detect IBD associations. Overall, in these population-based samples we failed to detect rare variations associated with HCV clearance in individuals of European ancestry and African Americans, and we didn't detect local ancestry-specific effects associated with HCV clearance in African Americans with our current sample size.