Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases
This study provides the first comprehensive characterization of tRF expression in CRLM, identifying distinct prognostic roles for ge- and mt-tRFs. While ge-tRFs correlated with poor prognosis, several mt-tRFs were linked to favorable outcomes, highlighting their potential as novel prognostic biomarkers and therapeutic targets.
Authors
- Johannes Laengle (ORCID: https://orcid.org/0000-0003-4771-1398)
- Christoph Schwarz (ORCID: https://orcid.org/0000-0002-7676-2779)
- Patrick P. Starlinger (ORCID: https://orcid.org/0000-0002-4666-5337)
- Dietmar Pils (ORCID: https://orcid.org/0000-0002-8355-0977)
- Andreas Renner (ORCID: https://orcid.org/0000-0002-1414-5433)
- Michael Bergmann (ORCID: https://orcid.org/0000-0001-8529-1166)
- Stefan Stremitzer (ORCID: https://orcid.org/0000-0002-4815-4135)
- Klaus Kaczirek
- N Hartman
- Polina Kalinina (ORCID: https://orcid.org/0000-0003-0278-9044)
- Rebecca Zirnbauer (ORCID: https://orcid.org/0000-0002-3921-4001)
- Daphni Ammon (ORCID: https://orcid.org/0000-0001-9969-3430)
Institutions
- Comprehensive Cancer Center Vienna (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s12967-025-06850-3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Roche
- Österreichischen Akademie der Wissenschaften
- Universität Wien
- Medizinische Universität Wien
- Österreichische Gesellschaft für Chirurgische Onkologie