Cetobacterium somerae-derived argininosuccinic acid promotes intestinal and liver ureagenesis to alleviate ammonia intoxication
In summary, this study found that the role of probiotics in enhancing the host's resistance to AI depends on the function of ARA generated by CSC. AI can lead to depletion of ARA and interrupting ureagenesis, while CSC-produced ARA supplements ureagenesis in the liver and intestines, facilitating ammonia detoxification into urea. Video Abstract.
Authors
- Muzi Zhang (ORCID: https://orcid.org/0000-0001-5647-8204)
- Xue Li (ORCID: https://orcid.org/0000-0002-3072-0573)
- Shidong Wang (ORCID: https://orcid.org/0000-0002-6308-3208)
- Ming Li (ORCID: https://orcid.org/0000-0003-4399-7827)
Institutions
- Ningbo University (CN)
- Guizhou University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s40168-025-02152-4
- Citations
- 8
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 8.96
Funders
- National Natural Science Foundation of China