Reduced miR-338-3p contributes to polycystic ovarian syndrome by inhibiting proliferation and enhancing apoptosis
Reduced miR-338-3p levels have potential predictive value in distinguishing individuals with PCOS patients from normal population. Mechanistically, this microRNA regulates the PTEN gene to inhibit granulosa cell proliferation and promote apoptosis, thereby contributing to the pathological processes of PCOS.
Authors
- Huafang Wei (ORCID: https://orcid.org/0000-0002-8087-0262)
- Lin Liang (ORCID: https://orcid.org/0000-0002-7927-560X)
- Ying Chen (ORCID: https://orcid.org/0000-0001-8218-6889)
- Chengwen Song (ORCID: https://orcid.org/0000-0002-3354-9898)
- Wěi Li (ORCID: https://orcid.org/0000-0002-9522-4474)
- Jie Lv (ORCID: https://orcid.org/0000-0001-8655-4992)
Institutions
- Central Hospital of Wuhan (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s41065-025-00498-1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province