Platelet‐Induced <scp>NET</scp> in Liver Cirrhosis: Mitochondrial <scp>ROS</scp> ‐Mediated <scp>NETosis</scp> and Its Contribution to the Hypercoagulable State
Cirrhotic platelets induced NETs formation through mtROS and autophagy, which heightened the procoagulant activity and impaired the anticoagulant activity of thrombomodulin.
Authors
- Valerie A. Novakovic (ORCID: https://orcid.org/0000-0002-9846-0907)
- Shaohong Fang (ORCID: https://orcid.org/0000-0001-8635-857X)
- Jialan Shi (ORCID: https://orcid.org/0000-0001-5642-5436)
- Haijiao Jing (ORCID: https://orcid.org/0000-0002-8506-4016)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-1791-3768)
- Xiaoming Wu (ORCID: https://orcid.org/0000-0002-4271-8534)
- Cong Zhang (ORCID: https://orcid.org/0000-0001-6423-5069)
- Mengdi Li (ORCID: https://orcid.org/0000-0002-8504-5261)
- Huan Liu (ORCID: https://orcid.org/0009-0000-3166-7826)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harvard University (US)
- Harbin Medical University (CN)
- VA Boston Healthcare System (US)
- Dana-Farber Cancer Institute (US)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Liver International
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1111/liv.70223
- Citations
- 3
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- China Postdoctoral Science Foundation