Curvulomycin E, a New Resorcylic Acid Lactone From the Beibu Gulf Coral‐Derived Fungus <i>Curvularia lunata</i> GXIMD 02512
One new resorcylic acid lactone (RAL), curvulomycin E (1), along with 10 known compounds (2-11), was obtained from the Beibu Gulf coral-derived fungus Curvularia lunata GXIMD 02512. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature. The absolute configurations of 1 and 10 were accomplished by ECD calculations. Structurally, curvulomycin E (1) with a methoxy substituent at C-12 is generally uncommon in the 12-membered RAL family. Compounds 2-4 exhibited cytotoxicity against MDA-MB-231 and KTC-1 cells with IC<sub>50</sub> values ranging from 10.8 to 26.5 μM. The preliminary structure-activity relationship is discussed. Compound 2 further arrested the cell cycle at the S phase and dose-dependently induced apoptosis in MDA-MB-231 cells.
Authors
- Hong Zhang (ORCID: https://orcid.org/0000-0002-3930-6731)
- Xiaowei Luo (ORCID: https://orcid.org/0000-0002-2114-1609)
- Guihua Yang (ORCID: https://orcid.org/0000-0003-0743-6213)
- Xinjian Qu
- Miaoping Lin
- Yonghong Liu (ORCID: https://orcid.org/0000-0003-2307-5200)
- Cheng‐Hai Gao
- Xin Qi (ORCID: https://orcid.org/0000-0002-3200-3500)
- Chaonan Wang (ORCID: https://orcid.org/0009-0009-0564-9160)
Institutions
- Guangxi University of Chinese Medicine (CN)
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Magnetic Resonance in Chemistry
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1002/mrc.70014
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi University
- Division of Graduate Education