Serous Endometrial Adenocarcinoma (SEA) and Mixed Müllerian Tumor of the Ovary (MMOT): A Report Case

Serous endometrial adenocarcinoma (SEA) and mixed mullerian tumor of the ovary (MMOT) are two rare, highly aggressive tumor entities arising from the mullerian epithelium. Despite their distinct localization, they share many morphological, immunohistochemical and molecular features, including a high frequency of TP53 mutations, loss of hormonal expression and a high-grade serous signature. Their prognosis is unfavorable, largely due to late diagnosis, early dissemination and limited response to standard treatments. Cytoreductive surgery and platinum-based chemotherapy are the mainstays of treatment, although their efficacy remains limited, particularly in TMMO. However, recent advances in molecular biology are paving the way for targeted therapeutic approaches, including immunotherapy. A better understanding of the biology of these tumors will help optimize their management and improve patient survival.