Dysregulation of immune cells and platelet-monocyte aggregates in chronic thromboembolic pulmonary hypertension
Immune cell subpopulations in CTEPH can be efficiently analyzed using the low blood volume flow cytometry approach. Peripheral blood immune cell dysregulation points to an active immune response in CTEPH. Insights into the pathophysiology of CTEPH may be gained by using PMA as a biomarker for assessing the severity and treatment outcomes of CTEPH. However, more research is needed to determine PMA's role in CTEPH for disease diagnosis assessment and pathogenesis.
Authors
- Yuhan Li
- Han Tian
- Zhenguo Zhai (ORCID: https://orcid.org/0000-0002-7096-8792)
- Shiqing Xu (ORCID: https://orcid.org/0000-0003-4896-2930)
- Xincheng Li (ORCID: https://orcid.org/0009-0009-2806-9644)
- Qiang Huang (ORCID: https://orcid.org/0000-0002-4363-6805)
- Min Liu (ORCID: https://orcid.org/0000-0003-1298-4441)
- Peiran B Yang (ORCID: https://orcid.org/0000-0002-4635-1215)
- Ran Miao
- Shuai Zhang (ORCID: https://orcid.org/0000-0002-9818-7760)
- Zhu Zhang (ORCID: https://orcid.org/0000-0001-5009-4680)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-2560-3927)
- Haobo Li (ORCID: https://orcid.org/0000-0002-1882-5831)
- Jixiang Liu (ORCID: https://orcid.org/0000-0003-1179-4443)
- Lu Sun
- Ximei Niu
- Wanmu Xie (ORCID: https://orcid.org/0000-0002-6686-3517)
Institutions
- Xinjiang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
- Wuhan Sixth Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s12931-025-03284-9
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China