Bromodomain-containing protein 4 contributes to chronic postsurgical pain via activating TLR4/NF-kappaB-dependent neuroinflammation
The epigenetic regulator Brd4 initiates neuroinflammation in spinal cord through activating TLR4/NF-κB signaling pathway and enhancing cytokine and chemokines release, thereby contributing to the transition to chronic postsurgical pain. JQ1 halts chronic pain development, providing a novel therapy for patients at high risk of persistent pain.
Authors
- Zengli Zhang (ORCID: https://orcid.org/0000-0002-0108-0263)
- Yiqing Yin (ORCID: https://orcid.org/0009-0003-7969-8025)
- Xuan Zhang (ORCID: https://orcid.org/0000-0003-2937-9141)
- Yuan Li (ORCID: https://orcid.org/0000-0003-4335-1612)
- Kaiyuan Wang (ORCID: https://orcid.org/0000-0002-1114-6481)
- Shu Guan (ORCID: https://orcid.org/0000-0002-7296-6213)
- Ruichen Shu
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s12871-025-03216-6
- Citations
- 1
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China