Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway

Obesity triggers a phenotypic change in gastric SMCs, driven by the activation of the PPARD/PDK4/ANGPTL4 pathway. These mechanistic insights offer potential biomarkers for diagnosing stomach dysmotility in patients with obesity.

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Publication Details

Journal
Journal of Biomedical Science
Published
2025-07-12
DOI
https://doi.org/10.1186/s12929-025-01163-5
Citations
2
Primary Topic
Lipid metabolism and disorders
Type
article
Field-Weighted Citation Impact
2.78

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article

Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway

Guillaume Walther, David Nocca, Nicolas Cénac, Amandine Falco et al.
2 citations
Journal of Biomedical Science
Lipid metabolism and disorders
2.78
article

Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway

Guillaume Walther, David Nocca, Nicolas Cénac, Amandine Falco, Cyril Breuker, Sandrine Faure, Karidia Konate, Sanaa Dekkar, Sarah Maurel, Florian Pallot, Pascal de Santa Barbara, Norbert Chauvet, Ariane Sultan, Laurent Maı̈moun, Prisca Boisguérin, Kamilia Mahloul, Romane Pisteur
article en
2 citations

Abstract

Obesity triggers a phenotypic change in gastric SMCs, driven by the activation of the PPARD/PDK4/ANGPTL4 pathway. These mechanistic insights offer potential biomarkers for diagnosing stomach dysmotility in patients with obesity.

Journal of Biomedical ScienceVol. 32(1)
Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), Inserm (FR), École Nationale Vétérinaire de Toulouse (FR), Université Fédérale de Toulouse Midi-Pyrénées (FR), Université d'Avignon et des Pays de Vaucluse (FR), Université de Montpellier (FR), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Centre Hospitalier Universitaire de Montpellier (FR), Institut de Recherche en Santé Digestive (FR)
Agence Nationale de la Recherche, Ministère de l'Enseignement Supérieur et de la Recherche
Good health and well-being
Openalex Percentile: Top 9%
Lipid metabolism and disorders
2.78
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