Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo
The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.
Authors
- Bertin C Bisimwa (ORCID: https://orcid.org/0000-0001-9278-7362)
- François Hakizayezu
- Steven Callens (ORCID: https://orcid.org/0000-0002-7245-527X)
- Leen Rigouts (ORCID: https://orcid.org/0000-0003-3301-9480)
- Bouke C. de Jong (ORCID: https://orcid.org/0000-0002-1017-4675)
- Maja Kiselinova (ORCID: https://orcid.org/0000-0002-0683-6840)
- Conor Joseph Meehan (ORCID: https://orcid.org/0000-0003-0724-8343)
- Isabel Cuella Martin (ORCID: https://orcid.org/0000-0001-7543-3386)
- Freddy Birembano
- Esto Bahizire (ORCID: https://orcid.org/0000-0002-7205-7730)
- Wim Mulders (ORCID: https://orcid.org/0000-0002-9566-3653)
- Jean Claude Semuto Ngabonziza (ORCID: https://orcid.org/0000-0002-6075-5603)
- Michel Kaswa (ORCID: https://orcid.org/0000-0003-3260-7248)
- Valéry Byela
- Docteur Runyambo
Institutions
- University of Nairobi (KE)
- University of Antwerp (BE)
- Ghent University Hospital (BE)
- University of Kigali (RW)
- University of Kinshasa (CD)
- University of Rwanda (RW)
- Université Catholique de Bukavu (CD)
- National Institute of Biomedical Research (CD)
- Programme National Multisectoriel de Lutte contre le sida (CD)
- Rwanda Biomedical Center (RW)
- Nottingham Trent University (GB)
- Instituut voor Tropische Geneeskunde (BE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s12879-025-11348-w
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vlaamse regering