Advanced Tumors Hinder Dendritic Cell Interstitial Motility by Deregulating cGMP

Major Finding: Dendritic cell (DC) migration to tumor-draining lymph nodes (tdLN) is markedly decreased in late-stage tumors. Concept: A PDE5/sGC-mediated imbalance of intracellular cGMP in DCs prevents optimal DC motility and persistence within tdLNs.Impact: This study suggests that targeting PDE5 with an FDA-approved inhibitor may promote DC-dependent antitumor immunity.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-063
Primary Topic
Adenosine and Purinergic Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

Advanced Tumors Hinder Dendritic Cell Interstitial Motility by Deregulating cGMP

Cancer Discovery
Adenosine and Purinergic Signaling
article

Advanced Tumors Hinder Dendritic Cell Interstitial Motility by Deregulating cGMP

article en

Abstract

Major Finding: Dendritic cell (DC) migration to tumor-draining lymph nodes (tdLN) is markedly decreased in late-stage tumors. Concept: A PDE5/sGC-mediated imbalance of intracellular cGMP in DCs prevents optimal DC motility and persistence within tdLNs.Impact: This study suggests that targeting PDE5 with an FDA-approved inhibitor may promote DC-dependent antitumor immunity.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 82%
Adenosine and Purinergic Signaling
DOISourceOpenAlex
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Advanced Tumors Hinder Dendritic Cell Interstitial Motility by Deregulating cGMP · Cancer Discovery (2025) | TGRS Research Map | TGRS