An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels
CSF oAβ levels rise in concert with rising tau levels. A new plate-based ELISA offers improved consistency, less sample volume, and lower cost, thus better suited to quantify this challenging analyte.
Authors
- Nagendran Ramalingam (ORCID: https://orcid.org/0000-0002-9459-3593)
- Tracy L. Young‐Pearse (ORCID: https://orcid.org/0000-0001-7846-1542)
- Shan‐Xue Jin
- Jean‐Pierre Bellier (ORCID: https://orcid.org/0000-0002-8758-8075)
- Alexandra M Lish
- Ting Yang (ORCID: https://orcid.org/0000-0002-5113-8611)
- Hyun‐Sik Yang (ORCID: https://orcid.org/0000-0002-8318-0443)
- Beth L. Ostaszewski
- Trebor Lawton
- Dennis J. Selkoe (ORCID: https://orcid.org/0000-0001-8846-9767)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Yi Xu
- Lei Liu (ORCID: https://orcid.org/0000-0002-4604-4629)
Institutions
- Heat Biologics (United States) (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-07-12
- DOI
- https://doi.org/10.1186/s13195-025-01802-x
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Brigham and Women's Hospital
- National Institutes of Health
- RIKEN