Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk
This study provides evidence that certain inflammatory factors, particularly artemin and MMP-10, are causally linked to ICC risk, identifying them as potential risk factors and therapeutic targeting. These findings enhance the understanding of the inflammatory components of the TME in ICC, supporting the development of targeted intervention strategies.
Authors
- Zhen Feng (ORCID: https://orcid.org/0000-0002-1986-9334)
- He Lv (ORCID: https://orcid.org/0000-0001-8780-6223)
- Jun Chen (ORCID: https://orcid.org/0000-0001-7186-8964)
- Guoping Jiang (ORCID: https://orcid.org/0000-0001-7823-1245)
- Zhitao Chen (ORCID: https://orcid.org/0000-0002-7054-6549)
- Bing Chen
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Shuren University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-07-12
- DOI
- https://doi.org/10.4251/wjgo.v17.i7.108455
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00