Neutrophil extracellular traps predict sensitivity to neoadjuvant chemotherapy combined with immunotherapy in locally advanced gastric cancer
Pre-NACI NET density serves as a prognostic and predictive biomarker for NACI efficacy in LAGC patients. Low pretreatment NET density is associated with favorable outcomes, while increased post-treatment NET density correlates with poorer response. Targeting NET formation may represent a novel therapeutic strategy to enhance NACI efficacy in LAGC.
Authors
- Ran An (ORCID: https://orcid.org/0000-0002-4849-0120)
- Lin Chen (ORCID: https://orcid.org/0000-0001-6935-1552)
- Tao Li (ORCID: https://orcid.org/0000-0002-9038-4794)
- Wenlei Li (ORCID: https://orcid.org/0000-0003-3960-6512)
- Yuan Lv (ORCID: https://orcid.org/0000-0003-3802-0966)
- Aijun Liu (ORCID: https://orcid.org/0000-0002-0467-9909)
- Liang Sun (ORCID: https://orcid.org/0000-0003-1634-4716)
- Hongyan Zhu (ORCID: https://orcid.org/0000-0002-3395-2222)
- Wentao Zhong
- Lingxia Xin
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-07-12
- DOI
- https://doi.org/10.4251/wjgo.v17.i7.105723
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00