Synthesis and Neurotropic Activity of Cyclic and Spirocyclic Derivatives of 1,3-Diazadamantane
Cyclic and spirocyclic 1,3-diazaadamantane derivatives were synthesized by the condensation of substituted 3,7-diazabicyclo[3.3.1]nonanes with cyclic and heterocyclic aldehydes and ketones. Screening for neurotropic activity showed that spirocyclic 1,3-diazaadamantanes exhibit a higher potency than their cyclic analogs, with activity levels of 40–60 against 20–40%, respectively.
Authors
- R. G. Paronikyan (ORCID: https://orcid.org/0000-0002-3845-6324)
- K. A. Gevorkyan (ORCID: https://orcid.org/0000-0003-3604-6038)
- A. D. Harutyunyan (ORCID: https://orcid.org/0000-0002-8320-0942)
- S. P. Gasparyan (ORCID: https://orcid.org/0000-0003-2341-724X)
- I. M. Nazaryan
- M. V. Galstyan (ORCID: https://orcid.org/0000-0002-9475-8810)
- M. V. Aleksanyan
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1134/s1234567825601330
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00