Synthesis of Heterocycles Based on 4,5-Dichlorophthalonitrile
The SNAr reaction of 4,5-dichlorophthalonitrile with various bifunctional nucleophiles was carried out in anhydrous DMF in the presence of K2CO3 as a deprotonating agent. It was shown that 4,5-dichlorophthalonitrile can be successfully employed in the synthesis of heterocyclic compounds; however, in some cases, these reactions may either give product mixtures or result in an unexpected rearrangement.
Authors
- V. V. Bukhalin
- V. V. Aleksandriiskii (ORCID: https://orcid.org/0000-0002-7986-6573)
- V. L. Baklagin (ORCID: https://orcid.org/0009-0003-5361-9085)
- И. Г. Абрамов (ORCID: https://orcid.org/0000-0002-8204-1660)
Institutions
- Ivanovo State University of Chemistry and Technology (RU)
- Yaroslavl State Technical University (RU)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1134/s1234567825600932
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00