Synthesis, Characterization, and Anticancer Activity of 2-Aminothiazole Derivatives

Eight novel 2-[(substituted)acetamido]thiazole-4-carboxylates were designed and synthesized as potential anticancer agents. The synthesized compounds were tested for in vitro cytotoxic activity against Panc-1 cells by the MTT assay and showed significant inhibition of cell proliferation. At 90 μM, ethyl 2-[2-(dibutylamino)acetamido]- and 2-[2-(4-methylpiperidin-1-yl)acetamidothiazole-carboxylates inhibited proliferation by > 50%, with the former demonstrating a particularly strong potency (IC50 = 43.08 μM). Further experiments showed the ethyl 2-(2-(dibutylamino)acetamido)thiazole-4-carboxylate also markedly inhibited Panc-1 cell migration, invasion, and adhesion, which positions this compound as a promising candidate for anticancer drug development.