Synthetic Approaches to Heterocyclic Scaffolds: 4-Thiazolidinone Derivatives as Heterocyclic Scaffolds: Synthesis and Biological Activity (A Review)

A comprehensive review of the authors’ research focused on the development of novel and efficient synthetic strategies for structurally diverse heterocyclic scaffolds is presented. Among these, the thiazolidinone scaffold has emerged as highly versatile and pharmaceutically significant framework in modern medicinal chemistry, owing to its broad clinical relevance. The review covers the recent literature on the design and synthesis of diverse 1,3-thiazolidin-4-one derivatives and investigation of their biological properties and highlights the tremendous potential of thiazolidinones in advancing organic and medicinal chemistry.