Synthesis of N,N-Substituted-Propargylaniline Derivatives by Coupling Reaction between N-aryl Propargylamine and α-Bromo Carbonyl Compounds.

Due to its importance, propargylamine and its derivatives have been a point of interest for our team. Ten new derivatives of propargylamine have been synthesized and characterized by 1H NMR and 13C NMR. The synthesis process was carried out in three steps: Firstly, aniline and its derivatives were propargylated. Secondly, bromination of acetophenone and its derivatives was carried out. Lastly, the products of the previous two reactions were reacted in mild conditions, and a mechanism of action is suggested.