Genetic Insights in Orthopedics Disorders: Paving the Way for Personalized Treatment

Personalized medicine is becoming a significant focus in many medical specialties, and Orthopedics is no exception. The role of genetic factors in the predisposition, progression, and treatment response of musculoskeletal conditions has been widely studied. This article explores how genetic markers are identified and linked to various Orthopedics conditions, enabling earlier and more precise diagnoses, particularly through genetic testing. It also underlines the potential of pharmacogenomics to personalize pain management and optimize treatments for bone health disorders by considering how genetic variations can affect the effectiveness of medications. Additionally, gene therapy and stem-cell-based regenerative medicine are discussed as promising approaches for tissue regeneration, especially in bone and cartilage repair. With continued advancements in these areas, there is optimism for more personalized and effective treatment strategies that can improve patient outcomes and reduce the need for trial-and-error treatments.

Authors

Publication Details

Journal
Global Journal of Orthopedics Research 
Published
2025-04-14
DOI
https://doi.org/10.33552/gjor.2025.04.000599
Primary Topic
Neurogenetic and Muscular Disorders Research
Type
article
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article

Genetic Insights in Orthopedics Disorders: Paving the Way for Personalized Treatment

Kamran Shirbache
Global Journal of Orthopedics Research 
Neurogenetic and Muscular Disorders Research
article

Genetic Insights in Orthopedics Disorders: Paving the Way for Personalized Treatment

Kamran Shirbache
article en

Abstract

Personalized medicine is becoming a significant focus in many medical specialties, and Orthopedics is no exception. The role of genetic factors in the predisposition, progression, and treatment response of musculoskeletal conditions has been widely studied. This article explores how genetic markers are identified and linked to various Orthopedics conditions, enabling earlier and more precise diagnoses, particularly through genetic testing. It also underlines the potential of pharmacogenomics to personalize pain management and optimize treatments for bone health disorders by considering how genetic variations can affect the effectiveness of medications. Additionally, gene therapy and stem-cell-based regenerative medicine are discussed as promising approaches for tissue regeneration, especially in bone and cartilage repair. With continued advancements in these areas, there is optimism for more personalized and effective treatment strategies that can improve patient outcomes and reduce the need for trial-and-error treatments.

Global Journal of Orthopedics Research Vol. 4(5)
Gender equality
Openalex Percentile: Top 76%
Neurogenetic and Muscular Disorders Research
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