Assessment of Therapeutic Potential of <i>Moringa oleifera</i> Leaves on Renal Impairment in Dogs in Braj Bhoomi Region of Uttar Pradesh, India

The present study was conducted to evaluate the therapeutic potential of Moringa oleifera leaves on renal impairment in dogs. For this, a total of 3881 dogs, irrespective of age, breed and sex presented to veterinary clinical complex, DUVASU, Mathura were examined. Total 287 dogs showed clinical signs concern to renal impairment, out of which 43 dogs were found positive for renal impairment by various clinical markers and laboratory tests. Twelve found positive for renal impairment during screening were taken for therapeutic study and randomly allocated into two groups, each group having six animals. In group B conventional treatment was given and in group C conventional treatment with combination of Moringa oleifera@ 30mg kg-1 body weight PO (per os-orally) was administered for 14 days. Six apparently healthy dogs were placed in healthy control group (group A) after thorough physical examination and various diagnostic tests. Treatment with conventional drugs as well as combination therapy with Moringa oleifera significantly reduced the concentration of Hb, TEC, PCV, Platelets as well as activities of the activities of serum creatinine, BUN, ALP, AST, GGT and renal biomarker protein cystatin-C and SDMA in renal impairment dogs. Based on results of the study it was concluded that Moringa oleifera may be advised as adjunct therapy along with conventional treatment for early recovery in renal impairment in dog.