Development of Formulation and Evaluation of Fexofenadine Hydrochloride Uncoated Tablet by Wet Granulation Method

The development and evaluation of Fexofenadine hydrochloride(HCl) uncoated tablets were aimed at formulating and effective and patient compliant dosage form for the treatment of allergic rhinitis and uticaria. The formulation process included the selection of suitable binder and lubricant to ensure uniformity and stability. The tablets were prepared using direct compression followed by evaluation of their physiochemical properties including weight variation test, hardness, friability, disintegration time and dissolution test.Result demonstrated that the developed Fexofenadine HCl uncoated tablets exhibited desirable characteristics with consistent release profiles, and satisfactory stability making them a promising formulation for clinical use. Purpose:The aim of this study is to formulate and evaluate fexofenadine HCl uncoated tablet for the effective treatment of seasonal allergy rhinitis and for treatment of chronic urticarial and to comply dissolution study with USP limits. Method:Fexofenadine hydrochloride uncoated tablet 250mg were manufacture using a wet granulation method. The powder blend and granule mixture were evaluated various pre-compression characteristics such as angle of repose, compressibility index and Hauser’s ratio. The tablet were evaluated for post compression features including weight variation, hardness, thickness, friability, disintegration time and dissolution test. Result: The result show that the F6 formulation 250mg of tablet were selected as the best formulation. Conclusion: Fexofenadine HCl available in market as film coated tablet form having slow release drug profiles. In this study it was tried to formulate Fexofenadine HCl by wet granulation method to improve drug release profile. Based on various study we have carried out six trails. Based on preliminary study various formulation studies F1- F6 were carried out different concentration of diluents, disintegrant, binders and lubricant are added. Fexofenadine HCl tablet were formulated by wet granulation method. From all trails we have confirmed F6 as confirmatory trail and evaluated for post compression parameter.