Proneural–mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import
Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
Authors
- Damarys Loew (ORCID: https://orcid.org/0000-0002-9111-8842)
- Kevin Joseph (ORCID: https://orcid.org/0000-0001-6317-8736)
- G Bourmeau (ORCID: https://orcid.org/0000-0003-3800-4077)
- Océane Anezo
- Alberto Ballestín (ORCID: https://orcid.org/0000-0002-7150-9758)
- Giorgio Seano (ORCID: https://orcid.org/0000-0002-7294-302X)
- Michelle Miranda
- Céline Vallot (ORCID: https://orcid.org/0000-0003-1601-2359)
- Florent Dingli (ORCID: https://orcid.org/0000-0002-7715-2446)
- A. Thomas
- Valentino Ribecco (ORCID: https://orcid.org/0000-0001-9348-4320)
- Laetitia Besse (ORCID: https://orcid.org/0000-0001-5031-652X)
- Cathy Pichol-Thievend
- Vidhya Madapusi Ravi (ORCID: https://orcid.org/0000-0003-0062-2099)
- Gaetano Gargiulo (ORCID: https://orcid.org/0000-0001-5414-4251)
- Jérémy H. Raymond (ORCID: https://orcid.org/0000-0002-8712-895X)
- J Reveilles (ORCID: https://orcid.org/0000-0002-1307-2367)
- Lin Wang (ORCID: https://orcid.org/0000-0002-0503-9727)
- Stéphane Liva
- Eve Moutaux
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Freiburg (DE)
- Max Delbrück Center (DE)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- University Medical Center Freiburg (DE)
- German Center for Neurodegenerative Diseases (DE)
- University of Oxford (GB)
- Quantitative BioSciences (US)
- Ludwig Cancer Research (GB)
- City of Hope (US)
- Dynamique de l'information génétique : bases fondamentales et cancer (FR)
- Beckman Research Institute
- Institut Curie (FR)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1093/neuonc/noaf160
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- Ludwig Institute for Cancer Research
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Institut National Du Cancer
- Sorbonne Université
- European Research Council