Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study
Organic CPP is characterized by a younger age at diagnosis, faster progression of puberty, and higher gonadotropin levels compared to idiopathic CPP. An LH peak >9.1 mIU/mL and a growth velocity >1.75 SD should be considered key diagnostic markers for identifying organic causes of CPP and guiding further investigation and treatment.
Authors
- Luigi Antonio Moscogiuri
- Donato Rigante
- Giorgio Sodero (ORCID: https://orcid.org/0000-0003-3711-4928)
- Aniello Meoli (ORCID: https://orcid.org/0000-0003-3343-4051)
- Marilea Lezzi
- Federica Arzilli (ORCID: https://orcid.org/0000-0002-3461-8664)
- Elena Malavolta
- Clelia Cipolla
- Francesco Gallo
- Anna Camporeale
Institutions
- Agostino Gemelli University Polyclinic (IT)
- Ospedale A. Perrino (IT)
Publication Details
- Journal
- Journal of Pediatric Endocrinology and Metabolism
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1515/jpem-2025-0174
- Citations
- 4
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 6.79