Advanced Liposomal CoQ10 Formulation by WBCIL: A Step Forward in Cardiovascular Nutraceutical Therapy

Coenzyme Q10 (CoQ10), or ubiquinone, is a lipid-soluble molecule essential for mitochondrial electron transport and cellular energy production. Its oral bioavailability is limited due to high molecular weight and hydrophobicity. West Bengal Chemical Industries Ltd. (WBCIL), Kolkata, India, addressed this by formulating a liposomal CoQ10 using 75% sunflower-derived phosphatidylcholine. This study comprehensively characterizes the liposomal CoQ10 in terms of physicochemical properties, encapsulation efficiency (EE%), stability, and controlled release. Analytical methods including High Performance Liquid Chromatography (HPLC), Fourier Transform Infrared (FTIR) Spectroscopy, X-ray Photoelectron Spectroscopy (XPS), Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and thermal profiling confirmed structural integrity, particle uniformity, and enhanced encapsulation. For liposome characterisation, HPLC, FTIR, XPS, DLS, SEM, and thermal profiling confirmed structural integrity, particle uniformity, and enhanced encapsulation. HPLC showed 82.05% phosphatidylcholine and 10.82% phosphatidylethanolamine (93% total phospholipids). FTIR confirmed functional groups with C=O (~1738 cm⁻¹), CH₂ (~2853, ~2920 cm⁻¹), and –OH (3138–3320 cm⁻¹). XPS showed a surface composition of C (81.14%), O (17.61%), and P (1.25%). DLS showed particle sizes of 133.9 nm (PDI: 0.294) and 150.2 nm (PDI: 0.3286), with zeta potentials of –31.87 mV and –37.21 mV, indicating good colloidal stability. SEM confirmed smooth, spherical vesicles. For Liposomal CoQ10, EE% was 81.51%, surpassing the 70% benchmark. Accelerated stability (40°C ± 2°C, 75% ± 5% RH) showed EE% remained above 81% over six months. Thermal testing (105°C for 4 hours) confirmed structural integrity, supported by DSC analysis. These findings validate WBCIL’s liposomal CoQ10 as a highly stable, bioavailable, and effective alternative to conventional CoQ10 supplements.