Oral Cell Cancer: Could Intratumoral Microvessel Density (MVD) Hold the Key to Understanding the Antiangiogenic Effects of Efavirenz

Introduction: in addition to some studies which suggested that Efavirenz [EFV] may have anti-proliferative effects on various cancer cell lines even at sub-therapeutic doses, EFV has been reported to strongly impact angiogenesis and disrupt neutral lipid homeostasis. The aim of this paper is to bring to light the potential role Intratumoral Microvessel Density (MVD) holds in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer. Aims and objectives: to focus attention on the potential role Intratumoral Microvessel Density (MVD) holds in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer. Methods: This paper aims to draw attention on the Intratumoral Microvessel Density (MVD) as a potential factor in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer. Result : Our data analysis revealed that EFV treatments did not exhibit significant main effects on the viability of the cancer cell line (F (6,20) = 0.7970; p =0.5878). One-way Analysis of Variance (ANOVA) was used to determine the efficacy of the drug, at 0.05 significance level (p ≤ 0.05). Discussion/Conclusion: The results indicate that Efavirenz holds promise as an anti-proliferative agent for treating oral cancer. Nevertheless, additional research is necessary to fully explain the impact of the Intratumoral Microvessel Density (MVD) in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer. Keywords: Cal 27 cells ; Efavirenz; anti-mitotic; oral squamous cell; anti-angiogenic; AIDS -defining cancers; anti-proliferative; Apoptosis