Study of Bacteriological profile and their Antibiotic susceptibility profile of Bacterial respiratory tract infection among patient visiting outpatient department of respiratory medicine in a Tertiary Care Hospital in Bangladesh

Background: Respiratory tract infections are the most commoninfectious diseases in human. It is a significant health concern for mortality and morbidity in many developing countries. Antibiotic susceptibility varies from country to country and even among the health centers. Proper identification of causative pathogens and their antibiotic susceptibility testing is needed to select appropriate antibiotic therapy for management of patient suffering from Respiratory tract infections. Objectives:This study was aimed to determine the correct spectrum of bacterial pathogen causing respiratory tract infections with whir antimicrobial susceptibility profile of patient visiting outpatient department of respiratory medicine in Dhaka National Medical Institute Hospital, Bangladesh. Methods: This cross sectional observational sturdy was conducted in Dhaka National medical Institute hospital form October 2020 to March 2021. A total of 135 sputum sample were collected aseptically from patients who were clinically suspected to have respiratory infection. Sputum sample received from the patient were culture, identified and antibiotic sensitivity pattern performed by standard methods. Result: Out of 135 processed specimens 64(47.4%) yielded significant growth of Organism. Among 64 culture positive, 12 (18.75%) were gram positive Cocci, 52 (81.25%) were gram negative organism. The prevalence of the bacterial species among the gram positive were as fallows staphylococcus aureus 8 (66.67%) and streptococcus pneumonia 4(33.33%) among the gram negative isolates Klebsiellaspecies 25(48.07%) was the predominant followed by E.Coli 14(2692%), pseudomonas species 11(21.57%). Antimicrobial susceptibility pattern shown in total organism found that they are highly sensitive to Imipenem(100%), Amikacin (89%) Levofloxacin (88%), Ciprofloxacin (84%). Moxifloxacin (81%) and highly resistant to Amoxycillin (91%), Cefixime (66%) and Co-Amoxyclav (61%) Conclusion: Gram negative bacteria were predominant, most of the bacteria showed high resistant to commonly used antibiotics and this antimicrobial resistances is a matter a concern for the treatment of respiratory tract infections. J. Dhaka National Med. Coll. Hos. 2024; 30 (02): 42-46