Simulation of Proton Radiotherapy in the Clinical Treatment of Typical Osteosarcoma and the Treatment Design with Spread-Out Bragg Peak

Proton radiotherapy is a plausible approach in the clinical treatment of osteosarcoma, when conservative therapies are demanded. This article mainly focuses on the modeling and simulation of proton beams on typical osteosarcoma using TRIM, as well as the design for a spread-out Bragg peak to optimize the effect of proton radiotherapy. In the treatment plan, a composite proton beam with a discrete spectrum composed of 24 monochromatic proton beam is designed. The energy range is from 50MeV to 73MeV. The simulation roughly produces a flat SOBP plateau within the entirety of the tumor with σ = 0.327.