Psychotropic activity evaluation of bromantane — N-(camphan-2-yl)anilines new structural analogues in in vivo tests

The aim of the work was the synthesis of bromantane - N-(camphan-2-yl)anilines new structural analogues and the study of their psychotropic properties. Materials and methods. The synthesized compounds were identified using the NMR spectroscopy. The purity of the compounds was confirmed by a GC-MS analysis. Psychotropic properties of N-(camphan-2-yl)anilines were studied in the experiments on the Wistar rats aged 18-20 weeks, the mice (12 weeks old) obtained from the “Stolbovaya” nursery using the following tests: the “Open Field”, the “Elevated Plus Maze”, the “Novel Object Recognition”, the “Vogel Conflict”, the “Tail Suspension”, the “Tightrope suspension”, the “Extrapolation” test. Results. A series of new camphor aromatic amines, structural analogues of bromantane, were obtained and their psychotropic effects were evaluated by in vivo biological studies. Based on the results, it was possible to identify a leader compound, i.e. (1 R ,2 R ,4 R )-1,7,7-trimethyl- N -(4-ethylphenyl)bicyclo[2.2.1.1]heptan-2-amine (4e), which had a pronounced anxiolytic effect. Substance 4f showed cognitive properties in the “Novel Object Recognition” and the “Extrapolation” tests. The fact was established by the indices of the time of learning a novel object and the time of diving. Conclusion. The obtained data testify to the prospect of searching for substances with a psychotropic action in the range of aromatic camphor amines. Substance 4f, which deserves an in-depth study of the spectrum and mechanism of its psychotropic action, should be singled out separately.