Cardioprotective potential of shikonin in cardiac hypertrophy is mediated through PKM2/c-Myc/PTBP1/HIF-1α signaling pathway
Thus, our results demonstrated that SK modulates the PKM2/c-Myc/PTBP1/HIF-1α pathway mediated by PKM2 inhibition, which might be responsible for SK-mediated cardioprotection in ISO-induced CH.
Authors
- Shyam Sunder Sharma (ORCID: https://orcid.org/0000-0002-4221-4870)
- Mohd Rihan (ORCID: https://orcid.org/0000-0003-0632-9280)
Institutions
- National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
Publication Details
- Journal
- Indian Journal of Pharmacology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.4103/ijp.ijp_742_24
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00