IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer
The interaction between m6A and APA is mediated by the m6A regulator IGF2BP2 and the APA factor CPSF6. The transcripts harboring m6A modification tend to use the proximal polyadenylation signal (PAS) in ovarian cancer (OC). PUM2 promotes the malignant progression of OC through its m6A methylation and APA processing.
Authors
- Xinzhao Zuo (ORCID: https://orcid.org/0000-0003-2001-9932)
- Qinglv Wei (ORCID: https://orcid.org/0000-0002-6693-3917)
- Jing Xu (ORCID: https://orcid.org/0000-0001-8084-5609)
- Ningxuan Chen
- Ping Yi (ORCID: https://orcid.org/0000-0001-7111-6308)
- Jilei Xu (ORCID: https://orcid.org/0000-0001-5743-6807)
- Xiaoyan Jiang (ORCID: https://orcid.org/0000-0002-8974-7340)
- Bin Gu (ORCID: https://orcid.org/0000-0002-9787-6505)
- Tao Liu (ORCID: https://orcid.org/0000-0002-1482-4858)
- Xin Luo
- Yong Zhu (ORCID: https://orcid.org/0000-0002-0202-8248)
- Lingcui Xie
- Hongyan Zhao (ORCID: https://orcid.org/0009-0006-4263-0811)
- Xiaoyi Liu
- Yang Yu (ORCID: https://orcid.org/0000-0001-6584-4050)
Institutions
- Hubei University of Medicine (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/ctm2.70388
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China