MiRNA‐501‐3p and MiRNA‐502‐3p: A promising biomarker panel for Alzheimer's disease
MiR-501-3p and miR-502-3p expression is elevated in AD CSF exosomes, AD serum exosomes, AD B-lymphocytes and Aβ- and Tau-treated cells. MiR-501-3p and miR-502-3p are correlated with amyloid plaque and NFT tangle density in specific brain regions. MiR-501-3p and miR-502-3p are highly expressed in neurons and astrocytes, suggesting that these cells are the source of miRNA secretion. MiR-501-3p and miR-502-3p could be a promising biomarker panel for AD.
Authors
- Ahna L. H. Pai (ORCID: https://orcid.org/0000-0002-5958-4157)
- Bhupender Sharma (ORCID: https://orcid.org/0000-0001-9141-5815)
- Gunjan Goyal (ORCID: https://orcid.org/0000-0002-1205-7077)
- Davin Devara (ORCID: https://orcid.org/0000-0003-4793-9907)
- Subodh Kumar (ORCID: https://orcid.org/0000-0003-4705-122X)
- Aditi Kulkarni (ORCID: https://orcid.org/0000-0003-4200-1987)
- Nathan Tinu
- Daniela Rodarte
Institutions
- Texas Tech University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/ctm2.70389
- Citations
- 8
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 7.49