The Effects of Tocilizumab on Inflammatory and Differentiation Pathways in Primary Human Chondrocytes: A Bioinformatic and In Vitro Approaches
These findings highlight Tocilizumab's role in modulating inflammation and differentiation pathways in human primary chondrocytes. Further studies should explore the long-term effects of IL-6 blockade on cartilage remodeling and regenerative capacity in chronic inflammatory settings.
Authors
- Duygu Yaşar Şirin (ORCID: https://orcid.org/0000-0002-1224-442X)
- Bugrahan Regaip Kilinc (ORCID: https://orcid.org/0000-0001-5892-5928)
- Suray Pehlivanoğlu (ORCID: https://orcid.org/0000-0001-7422-2974)
- Feyza Kostak
- Ömer Yılmaz (ORCID: https://orcid.org/0000-0002-0962-2725)
Institutions
- Tekirdağ Namık Kemal University (TR)
- Necmettin Erbakan University (TR)
- Sivas State Hospital (TR)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/1756-185x.70336
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Tekirdağ Namık Kemal Üniversitesi