Longitudinal tau aggregation, atrophy, and cognitive decline in Alzheimer's disease
Baseline and longitudinal regional tau-PET uptake were more closely associated than structural MRI with longitudinal cognitive decline. Baseline tau-PET was a stronger determinant of longitudinal cognitive decline than longitudinal tau-PET. Simulated reductions of tau-PET accumulation showed limited alterations of cognitive trajectories, with potential implications for tau-targeting therapies.
Authors
- Ellen H. Singleton (ORCID: https://orcid.org/0000-0002-6034-8688)
- Alexa Pichet Binette (ORCID: https://orcid.org/0000-0001-5218-3337)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Olof T. Strandberg
- Niklas Mattsson (ORCID: https://orcid.org/0000-0002-8885-7724)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
Institutions
- Lund University (SE)
- Amsterdam Neuroscience (NL)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70435
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Alzheimer's Association
- GHR Foundation
- Lunds Universitet
- Hjärnfonden
- Vetenskapsrådet
- Skånes universitetssjukhus
- Parkinsonfonden
- European Research Council