Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease
Global <sup>11</sup>[C]-Pittsburgh compound B (PiB) standardized uptake value ratio (SUVR), cortical thickness, p-tau181, and p-tau231 differed between groups Differences were unaffected by age, sex, apolipoprotein E *4 (APOE*4), education, and Mini-Mental State Examination (MMSE) score Racialization needs more consideration in Alzheimer's disease clinical research Additional work is needed to understand the sources of biomarker differences.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Lilcelia A. Williams (ORCID: https://orcid.org/0000-0003-1207-1861)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Ann D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Anum Saeed (ORCID: https://orcid.org/0000-0003-1783-678X)
- Theresa Chapple‐McGruder
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Alexandra Gogola (ORCID: https://orcid.org/0000-0002-8798-1715)
- Brian J. Lopresti
- Davneet Minhas (ORCID: https://orcid.org/0000-0002-0217-6777)
- Cristy Matan
- Oscar L. López (ORCID: https://orcid.org/0000-0002-8546-8256)
- Henrik Zetterberg
- Kaj Blennow
Institutions
- University of Pittsburgh (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Geriatric Research Education and Clinical Center (US)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- VA Pittsburgh Healthcare System (US)
- University of Pittsburgh Medical Center (US)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70463
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- EU Joint Programme – Neurodegenerative Disease Research
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- National Institute on Aging