Subcortical gray matter volumes and 5‐year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi‐cohort analysis
Seven thousand seventy-six participants from three large longitudinal cohorts were followed for a maximum of 5 years. Hippocampal volume is associated with 5-year risk of dementia in subjective cognitive decline (SCD) or mild cognitive impairment (MCI). Amygdalar volume is associated with a 5-year risk of dementia in SCD or MCI. Stratifying by SCD and MCI revealed no consistent major differences.
Authors
- Meike Willemijn Vernooij (ORCID: https://orcid.org/0000-0003-4658-2176)
- Frank J. Wolters (ORCID: https://orcid.org/0000-0003-0358-1675)
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Pieter van der Veere
- Jacqueline J. Claus (ORCID: https://orcid.org/0000-0001-7047-7064)
- Vikram Venkatraghavan (ORCID: https://orcid.org/0000-0001-9759-0462)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Tavia E. Evans (ORCID: https://orcid.org/0000-0003-2390-286X)
- M. Arfan Ikram
- Mathijs T. Rosbergen
Institutions
- Erasmus MC (NL)
- Amsterdam Neuroscience (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70413
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Alzheimer's Association
- ZonMw
- Erasmus Universiteit Rotterdam
- Ministerie van Volksgezondheid, Welzijn en Sport
- Erasmus Medisch Centrum
- Ministerie van Onderwijs, Cultuur en Wetenschap
- Vereniging Trustfonds Erasmus Universiteit Rotterdam
- Alzheimer Nederland