Discrepancies between CSF biomarker and PET determinations of elevated brain amyloid and their prognostic significance
Discrepant abnormal cerebrospinal fluid (CSF) and positron emission tomography (PET) brain amyloid indicators are uncommon in mild cognitive impairment (MCI). CSF-PET discrepant persons with MCI tend to have less abnormal values initially. CSF-PET discrepant persons with MCI have a benign prognosis at 4 years.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Bryan J. Neth (ORCID: https://orcid.org/0000-0003-2342-0000)
- Derek Richard Johnson (ORCID: https://orcid.org/0000-0002-4217-5517)
- Jonathan Graff‐Radford
- Stephen D. Weigand (ORCID: https://orcid.org/0000-0002-4541-9011)
- Vijay K. Ramanan (ORCID: https://orcid.org/0000-0001-6591-8734)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Hugo Botha (ORCID: https://orcid.org/0000-0003-4390-685X)
- Stuart J. McCarter (ORCID: https://orcid.org/0000-0001-8158-8835)
- Joshua A. Bornhorst (ORCID: https://orcid.org/0009-0003-9297-3271)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Neill R. Graff‐Radford
- Ronald C. Petersen
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
- Kejal Kantarci
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70468
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Eli Lilly and Company
- Pfizer
- Biogen
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging