Commentary on “It is time to share Alzheimer biomarker results in dementia with Lewy bodies”

Many people with dementia with Lewy bodies (DLB) have evidence of Alzheimer's disease (AD) co-pathology, which can be assessed in vivo using biomarkers. In this issue, Armstrong and colleagues argue that it is now timely to disclose such AD biomarker results to people with DLB. They provide logical and powerful arguments, including the right for people to know and the value of this information in informing outcome and management. However, there are also important caveats to consider and a careful balance needs to be maintained between, on the one hand, the right to know and convey clinically useful information and, on the other, acknowledging the real uncertainty that exists regarding the true diagnostic and management implications of AD biomarkers in an individual with a DLB rather than an AD clinico-pathological syndrome.

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Publication Details

Journal
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Published
2025-07-01
DOI
https://doi.org/10.1002/dad2.70145
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Commentary on “It is time to share Alzheimer biomarker results in dementia with Lewy bodies”

John T. O’Brien
1 links
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Dementia and Cognitive Impairment Research
article

Commentary on “It is time to share Alzheimer biomarker results in dementia with Lewy bodies”

John T. O’Brien
article en

Abstract

Many people with dementia with Lewy bodies (DLB) have evidence of Alzheimer's disease (AD) co-pathology, which can be assessed in vivo using biomarkers. In this issue, Armstrong and colleagues argue that it is now timely to disclose such AD biomarker results to people with DLB. They provide logical and powerful arguments, including the right for people to know and the value of this information in informing outcome and management. However, there are also important caveats to consider and a careful balance needs to be maintained between, on the one hand, the right to know and convey clinically useful information and, on the other, acknowledging the real uncertainty that exists regarding the true diagnostic and management implications of AD biomarkers in an individual with a DLB rather than an AD clinico-pathological syndrome.

Alzheimer s & Dementia Diagnosis Assessment & Disease MonitoringVol. 17(3)
University of Cambridge (GB)
National Institute for Health and Care Research, Dementias Platform UK, Medical Research Council, NIHR Cambridge Biomedical Research Centre
Openalex Percentile: Top 80%
Dementia and Cognitive Impairment Research
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